患有腹部疼痛相关肠脑相互作用障碍的年轻人便症状的变化
Jason Lach1, Jennifer M Colombo2, Jennifer V Schurman2
1Department of Graduate Medical Education; Children's Mercy Kansas City, Kansas City, Missouri, USA.
刺激性肠综合征 (IBS) 的疼痛变化与便有显著差异. 在排便时增加的疼痛比减少的疼痛更符合IBS症状,夜间便可能表明eosinophilia.
科学领域:
- 胃肠病学
- 儿童胃肠病学
- 功能性胃肠疾病
背景情况:
- 刺激性肠综合征 (IBS) 的分类依赖于便的一致性和频率.
- 肠道运动带来的疼痛变化是IBS的一个关键症状,但在年轻人中描述不同.
- 了解疼痛的变化和夜间便对于诊断青少年的IBS至关重要.
研究的目的:
- 在被诊断为腹部疼痛相关性肠脑相互作用障碍 (AP-DGBI) 的青少年中调查便疼痛变化的特征.
- 确定这一患者群体中夜间便的流行率.
- 探索疼痛特征,夜间便和内镜发现之间的潜在关联.
主要方法:
- 通过罗马IV标准对300名AP-DGBI患者进行了评估.
- 标志性疼痛变化与便 (方向,频率,程度) 和夜间便的发生.
- 检查了140名患者的结肠镜检查结果.
主要成果:
- 59% 的患者表示疼痛没有改变,26. 7% 的患者表示疼痛有所减少,14. 3% 的患者表示疼痛有所增加.
- 在疼痛的方向,频率和程度上存在显著的变化.
- 晚间便 (19. 7%) 与较高的结肠炎症或低级别疹 (33%与15. 4%) 相关.
结论:
- 在IBS中,肠道排便带来的疼痛变化具有显著的异质性.
- 便时疼痛增加是一个比疼痛减少更一致的IBS症状.
- 在AP-DGBI中,夜间便相对较为常见,可能与粘膜菌相关.
更多相关视频
09:44Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
Published on: September 11, 2012
10:37Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
相关概念视频
Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Gastrointestinal Motility Disorders
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Other Disorders of Digestive System
