神经成像遗传学和发育精神病理学:一个系统的审查
Connor L Cheek1,2, Pavel V Dobrynin1,2, Galina V Khafizova1,2
1Texas Institute for Evaluation, Measurement and Statistics, University of Houston, Houston, TX, USA.
Development and psychopathology
|September 1, 2025
概括
图像遗传学将脑图像与遗传数据联系在一起, 以了解行为和神经发育障碍. 但需要更大的样本和新的方法才能取得进展.
科学领域:
- 综合神经成像和遗传数据的跨学科领域.
- 专注于理解大脑结构,功能和行为的遗传基础.
背景情况:
- 由于分子遗传学和神经图像学的进步, 图像遗传学已取得显著的进步.
- 它提供了研究个人认知和社会情感发展差异的新途径.
- 这些差异与神经发育障碍之间的联系是研究的关键领域.
研究的目的:
- 系统地审查图像遗传学的最新进展.
- 专注于2020年至2024年间发表的关于发展性精神病理的研究.
主要方法:
- 在PubMed/MEDLINE和PsycINFO进行了系统的文献搜索.
- 选了769篇文章,根据预先定义的纳入标准选择了42篇文章.
- 根据发育年龄组分类选择的研究:出生/幼儿,晚儿/早期青少年和晚青少年.
主要成果:
- 在过去的五年里, 在成像遗传学研究方面取得了实质性的进展.
- 突出了数据采集,分析和解释的持续挑战.
- 强调需要更大的样本和创新的分析技术.
结论:
- 图像遗传学的持续进步需要解决当前的方法限制.
- 较大的样本大小对于发展性精神病理学的强有力的发现至关重要.
- 动物研究可以为人类研究提供有价值的补充见解.
相关概念视频
Human Genetics
716
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
716
Behavioral Genetics and Its Designs
505
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
505
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
945
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
945
Introduction to Biological Bases of Psychology
3.5K
Biopsychology serves as a vital bridge connecting the intricate domains of biology and psychology, shedding light on how biological systems influence psychological phenomena. This field scrutinizes the biological substrates of behavior and mental processes, emphasizing the nervous system along with the roles of neurotransmitters, hormones, and genetics. It also incorporates evolutionary perspectives to explain the adaptive nature of mental functions.
The nervous system, the cornerstone of...
The nervous system, the cornerstone of...
3.5K
Biological Causes of Schizophrenia
145
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
145
Brain Imaging
310
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
310


