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Updated: Sep 9, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Published on: October 26, 2015

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开发D-box来抑制亚纳促进复合体/循环体

Rohan Eapen1, Cynthia Okoye1, Christopher Stubbs2

  • 1Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom.

eLife
|September 1, 2025
PubMed
概括

研究人员开发了针对细胞分裂中的关键蛋白质Cdc20的抑制剂. 这些D-盒通过抑制酶促进复合物/循环体 (APC/C) 并实现向蛋白质降解,对癌症治疗具有前景.

关键词:
在ACP/C大肠杆菌无相促进复合体/循环体生物化学化学生物学降级人类类抑制剂蛋白质与蛋白质的相互作用无处不在的

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