脊椎外科的ERAS协议中的 gabapentinoids:系统审查和元分析
Richard Wang1, Avrohom Karp1, Kevin Clare1
1School of Medicine, New York Medical College.
Clinical spine surgery
|September 1, 2025
概括
使用 gabapentinoids 进行脊椎手术的增强后恢复 (ERAS) 方案可能会减少住院时间. 在ERAS中使用GABAPENTINOID显示了与安慰剂相比的可比或改善的副作用,在脊椎手术文献中没有发现任何不良事件.
科学领域:
- 神经外科
- 麻醉学
- 药理学
背景情况:
- 手术后复原 (ERAS) 方案旨在优化手术结果.
- 在ERAS中经常使用 gabapentinoids来控制疼痛并减少阿片类药物消耗.
- 对于 gabapentinoid 的安全性存在担忧,尤其是在与阿片类药物结合使用时.
研究的目的:
- 在脊椎手术的ERAS协议中评估 gabapentinoids 的安全性和有效性.
- 进行相关研究的系统审查和元分析.
主要方法:
- 对ERAS脊椎外科手术方案的研究进行系统审查和元分析.
- 使用MeSH术语搜索PubMed以确定相关的ERAS和 gabapentinoid并发症研究.
- 分析了ERAS比较研究中的3045名患者和417名加巴类药物副作用研究中的数据.
主要成果:
- 与传统治疗相比,ERAS队列的停留时间 (LOS) 显著下降 (P<0.05).
- 与对照组相比,服用150毫克的普雷加巴林可显著减少恶心和吐 (P< 0. 05).
- 与安慰剂相比,不同剂量的 gabapentinoid 没有发现其他副作用的显著差异.
结论:
- 使用 gabapentinoids 的 ERAS 协议可能会缩短脊椎手术患者的住院 LOS.
- 与安慰剂相比,GABAPENTINOID镇痛剂在ERAS中似乎具有有利的副作用.
- 在经过检查的脊椎手术文献中,没有发现加巴类药物与阿片类药物的联合不良反应.
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