年轻发病痴呆症患者,晚发病痴呆症患者和没有痴呆症患者的目标体育活动:英国生物库研究
Nicholas H Lawlis1,2,3, Nicolas Cherbuin4, Ananthan Ambikairajah3,4,5,6,7
1UC Research Institute for Sport and Exercise, University of Canberra, Canberra, ACT, Australia.
Journal of Alzheimer's disease : JAD
|September 1, 2025
概括
患有年轻期痴呆症的人比晚期痴呆症更多地从事体力活动. 与对照组相比,晚期痴呆患者的活动较少,久坐时间较长,睡眠时间较长.
科学领域:
- 老年学
- 神经学
- 运动学
背景情况:
- 目前的体力活动研究往往忽视了年轻发病痴呆症 (在65岁之前被诊断出来) 和晚期发病痴呆症之间的区别.
- 年龄是影响身体活动的已知因素,但这种差异通常不会在痴呆症研究中得到解决.
研究的目的:
- 将年轻发病痴呆症,晚发病痴呆症和年龄相匹配的无痴呆症对照人群之间的客观体力活动水平进行比较.
主要方法:
- 对英国生物库参与者 (49-76岁) 的横截面分析.
- 分析了四组:年轻发病的痴呆症 (n=23),年轻发病的对照组 (n=782),晚期发病的痴呆症 (n=30) 和晚期发病的对照组 (n=918).
- 使用手腕加速度计,在7天内收集了光强度体力活动,中度至强度体力活动,久坐行为和睡眠的客观测量.
主要成果:
- 年轻发病痴呆症参与者比晚发病痴呆症参与者表现出较高的轻度和中度至强度的体力活动;当控制年龄时,这种差异会减少.
- 在年轻发病痴呆症和年轻发病对照组之间没有观察到身体活动的显著差异.
- 与晚期发病的对照组相比,晚期发病的痴呆症参与者表现出较少的光强度体力活动,更长的久坐时间和更长的睡眠时间.
结论:
- 这项研究揭示了年轻期和晚期痴呆症之间明显的身体活动模式.
- 未来关于体力活动和痴呆症的研究应该区分年轻和晚期发病的诊断.
- 这种区分对于开发适用于痴呆症患者一生的有针对性的干预措施至关重要.
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