儿科坟墓的轨道病: 136名中国患者的病例系列
Huan Jian1, Yanyan Zhu2, Weimin He3
1Department of Ophthalmology, West China Hospital, Sichuan University, No. 37 Guoxue Street, Chengdu, 610041, Sichuan, China.
International ophthalmology
|September 1, 2025
概括
儿童格雷夫斯轨道病 (GO) 患者,通常是青春期晚期的女性,通常出现轻微的症状和良好的预后. 观察通常是充足的,周周皮质类固醇注射被证明对必要的治疗有效.
科学领域:
- 眼科 眼科
- 内分泌学
- 儿童医学
背景情况:
- 格雷夫斯轨道病 (GO) 是一种影响眼的自身免疫性疾病.
- 小儿GO比成年GO少,可能有不同的临床特征.
研究的目的:
- 研究诊断为Graves轨道病的儿科患者的临床特征和治疗策略.
- 将儿童GO病例的严重程度和预后与成人病例进行比较.
主要方法:
- 在2009年至2023年期间在西中国医院接受GO治疗的136名儿科患者的回顾性分析.
- 收集的数据包括症状,临床症状,成像发现,治疗方法和患者的结果.
主要成果:
- 大多数患者 (83. 82%) 是女性,出现甲状腺功能过高 (86. 03%). 常见的症状包括眼外 (90. 44%) 和眼滞后 (90. 46%).
- 大多数病例呈现轻度 (65. 56%) 没有危及视力的情况. 最常见的是下直肠肌肉受影响 (44. 7%).
- 超过一半的患者 (51. 87%) 的首要方法是观察. 在41. 49%的患者中使用了皮质皮质类固醇注射,其严重性和活性显著改善.
结论:
- 与成年人相比,小儿GO患者,特别是青春期的女性,通常会出现较轻的疾病和更好的预后.
- 对于儿科GO,包括观察在内的保守治疗通常是足够的.
- 当需要干预时,外周皮质类固醇注射是一种有效的治疗选择.
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