在人体组织库中存储超过5年的骨组织是否安全?
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
在PubMed上查看摘要
概括
此摘要是机器生成的。人类组织库可以安全地存储骨移植长达10年. 包装保持完整性,无菌性和微生物保护,表明骨移植的保质期延长.
科学领域
- 生物医学工程
- 组织工程
- 材料科学
背景情况
- 人体组织银行 (BTH) 需要经过验证的组织存储长达5年.
- 评估存储的骨组织的长期活力和安全性对于移植至关重要.
研究的目的
- 评估存储9-10年的骨组织的安全性和完整性.
- 要确定包装在长时间储存期间是否保持物理完整性,无菌性和微生物保护.
- 在长时间储存后分析骨组织的形态变化.
主要方法
- 对骨组织和包装进行微生物学测试 (有氧/无氧细菌,真菌).
- 对骨组织进行细胞形态的组织学检查.
- 在包装上进行机械耐药性,燃烧性和细胞毒性测试.
- 储存介质的生物负荷检查
主要成果
- 在骨组织样本中没有检测到致病微生物.
- 组织学发现骨细胞保存, 但一些骨退化和死亡脂肪组织.
- 包装在储存后保持无菌性,非细胞毒性和非火热性.
- 机械测试显示包装保持了厚度,张力和刚性.
结论
- 包装保证骨组织的物理完整性,无菌性和微生物保护,长达9-10年.
- 这项研究支持将骨组织移植的保质期延长到10年.
- 这些发现鼓励进一步研究以提高BTH产品质量和服务寿命.
相关概念视频
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...