睡眠障碍和中风之间的肠道微生物介导因果关系:孟德尔随机化研究
Chunhua Li1, Kaimin Zeng1, Dingsheng Mo2
1Department of Neurology, The First Affiliated Hospital (People's Hospital of Hunan Province), Hunan Normal University, No. 61 West Jiefang Road, Changsha, 410006, Hunan Province, China.
概括
这项研究揭示了失眠和中风等睡眠障碍之间的因果关系. 肠道细菌,比如埃扎基叶植物,可能会调解这些风险, 这表明改善睡眠和肠道健康可以预防中风.
科学领域:
- 神经科学
- 微生物学
- 流行病学
背景情况:
- 睡眠障碍越来越多地被认为是中风的重要危险因素.
- 肠道微生物群对整体健康和疾病发病的作用是一个日益增长的研究领域.
- 然而,睡眠障碍,肠道微生物组成和中风之间的直接因果关系仍然很大程度上未确定.
研究的目的:
- 研究特定睡眠障碍与中风之间的因果关系,包括其亚型.
- 探索肠道微生物群在睡眠障碍和中风之间的潜在调解作用.
- 确定与中风风险相关的特定肠道微生物种群.
主要方法:
- 使用双样本门德尔随机化 (MR) 方法来评估因果关系.
- 使用逆方差加权 (IVW) 方法作为主要分析策略.
- 进行了强度敏感性分析,并使用系数产品方法来评估调解效应.
主要成果:
- 失眠与暂时性缺血性发作有因果关系 (OR=1. 592).
- 过度的白天睡眠与缺血性中风 (IS) 有因果关系 (OR=1. 887).
- 睡眠呼吸暂停与整体中风风险 (OR=1. 247) 有因果关系,而Ruminococcus E sp900314705 与中风风险增加有关. 埃扎基拉属植物部分介导了白天嗜睡和IS之间的联系 (15. 9%的效果).
结论:
- 睡眠障碍 (失眠,过度的白天嗜睡,睡眠呼吸暂停) 和中风之间确立了因果关系.
- 特定的肠道微生物群,包括Ruminococcus E和Ezakiellaceae,与中风风险相关.
- 突出了Ezakiellaceae在白天嗜睡和缺血性中风之间的关系中的调解作用,强调了潜在的治疗目标.
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