全片成像用于快速评估甲状腺FNA:多读者前性研究
Mohammed S Ahmed1, Dianna Klippel-Almaraz1, Sara E Amin2
1Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Cancer cytopathology
|September 1, 2025
概括
全片成像 (WSI) 是甲状腺细针吸收活检 (FNAB) 的快速现场评估 (ROSE) 的一个可行的选择. 这种数字方法显示了充分性和分类的高度一致性,支持其在细胞病理学中的实际应用.
科学领域:
- 细胞病理学
- 数字病理学
- 甲状腺诊断
背景情况:
- 甲状腺细针吸收活检 (FNAB) 的快速现场评估 (ROSE) 提高了诊断的充分性和分子检测.
- 对ROSE进行整片图像 (WSI) 的评估提供了传统光显微镜 (LM) 的数字替代方案.
研究的目的:
- 评估使用WSI治疗甲状腺FNAB的可行性.
- 将基于WSI的ROSE与LM检查进行样本充分性和贝塞斯达分类.
主要方法:
- 对98例甲状腺FNAB超声指导病例的前性研究.
- 细胞病理学家使用WSI和LM评估了样本的充分性和贝塞斯达分类.
- 使用kappa统计数据计算了观察者内部和观察者间的协议.
主要成果:
- 一般来说,WSI质量是可以接受的,对高放大或z堆叠的需求是最小的.
- 在 WSI 和 LM 之间观察到优异的内部协议 (κ=0.86-0.95).
- 对WSI (κ=0.48) 和LM (κ=0.56) 发现了适度的读者间一致性.
结论:
- WSI是甲状腺FNAB的可行的LM替代品.
- 很高的用户内部协议和可比的用户间协议支持了WSI的实用性.
- 这项研究强调了WSI在甲状腺细胞病理学中的实际应用.
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