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Single-cell RNA Sequencing of Fluorescently Labeled Mouse Neurons Using Manual Sorting and Double In Vitro Transcription with Absolute Counts Sequencing DIVA-Seq
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scSorterDL:用于单细胞分类的深度神经网络增强集体LDA

Kailun Bai1, Belaid Moa2, Xiaojian Shao3,4

  • 1Department of Mathematics and Statistics, University of Victoria, Victoria, BC V8P 5C2, Canada.

Briefings in bioinformatics
|September 1, 2025
PubMed
概括

scSorterDL通过整合处罚线性差异分析 (pLDA),群学习和深度神经网络 (DNN) 来提高单细胞RNA测序 (scRNA-seq) 中的细胞类型注释. 这种方法提高了不同数据集的分类准确性和稳定性.

关键词:
单元格类型注释深度神经网络处罚线性差异分析单细胞RNA测序群体学习

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Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
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