来自不同来源的食蛋白逃脱宿主消化,并通过肠道微生物群进行不同的修饰
Ayesha Awan1, Alexandria Bartlett1,2, J Alfredo Blakeley-Ruiz1
1Department of Plant and Microbial Biology, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, NC, 27606, USA. aawan2@ncsu.edu.
Food & function
|September 1, 2025
概括
饮食中的蛋白质来源对肠道微生物群和宿主健康有重大影响. 即使是易于消化的蛋白质也会进入结肠,
科学领域:
- 微生物学
- 营养科学
- 胃肠病学
背景情况:
- 饮食中的蛋白质对健康至关重要,
- 蛋白质消化及其在肠道微生物群中的命运尚未完全理解.
- 了解蛋白质来源对肠道微生物群的影响是解释不同健康影响的关键.
研究的目的:
- 调查来自各种来源的饮食蛋白质的宿主消化和肠道微生物群利用情况.
- 识别那些逃脱宿主消化并被肠道微生物代谢的特定蛋白质
- 阐明微生物活动如何影响肠道中饮食蛋白质的组成和命运.
主要方法:
- 使用高分辨率质谱测量量不同饮食来源的蛋白质.
- 在无细菌和常规培养小鼠中消化前后分析蛋白质概况.
- 在便样本中比较蛋白质降解和丰富.
主要成果:
- 在便中检测到来自所有来源的蛋白质,这表明即使是易消化的蛋白质也存在于结肠中.
- 肠道微生物显著降解了特定的饮食蛋白质,效率各不相同.
- 根据微生物存在,某些影响宿主健康的蛋白质表现出差异性丰富.
结论:
- 饮食中的蛋白质来源在胃肠道中表现出不同的命运.
- 肠道微生物群在食蛋白质的降解和转化中起着至关重要的作用.
- 宿主和微生物群的蛋白质加工差异可能解释不同的蛋白质来源对健康的影响.
相关概念视频
Protein Absorption
317
Proteins in the gastrointestinal tract typically come from food, but they can also originate from disintegrated cells or secreted enzymes. In the stomach, the enzyme pepsin breaks down these proteins into polypeptides. The fragments then move into the duodenum as a semi-fluid mass called chyme. Pancreatic proteases, such as trypsin and chymotrypsin, and intestinal brush border enzymes like carboxypeptidases further dismantle the polypeptides into tripeptides, dipeptides, and free amino acids.
317
Protein Digestion
105.6K
Protein digestion begins in the stomach, where the highly acidic environment can easily disrupt protein structure by exposing the peptide bonds of polypeptide chains. After polypeptide chains are broken into individual amino acids by a series of digestive enzymes, the amino acids are transported to the liver via the bloodstream to produce energy.
105.6K
Overview of Protein Metabolism
1.8K
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
1.8K
What is Monogastric Digestion?
72.5K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
72.5K
Amino Acid Catabolism
157
Microorganisms rely on proteins as an essential carbon and energy source, particularly in environments with limited polysaccharides or lipids. However, proteins are too large to cross the plasma membrane unaided, necessitating enzymatic degradation. Microbes secrete extracellular proteases and peptidases that hydrolyze proteins into peptides, which can then be transported across the membrane. Once inside the cell, intracellular proteases degrade these peptides into free amino acids, which...
157
Proteins: Dietary Sources and Requirements
606
Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
606


