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2017-2023年上海的HIV-1 CRF07_BC_N和CRF07_BC_O的流行动态和临床特征

Yingying Ma¹, Min Zhang², Le Cao¹

¹Basic Research, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

|September 1, 2025

概括

在中国,CRF07_BC,特别是07BC_N正在迅速扩大,超过了CRF01_AE. 这项研究详述了它的演变,传播和临床特征,揭示了07BC_N

科学领域:

病毒学和流行病学
HIV-1分子流行病学
公共卫生

背景情况:

在中国,CRF07_BC血统正在扩大,CRF07_BC_N (07BC_N) 血统正在占主导地位.
了解CRF07_BC的宿主内进化和临床特征对于有效的HIV-1管理至关重要.
之前的研究对中国CRF07_BC亚型的具体动态数据有限.

研究的目的:

系统地调查上海CRF07_BC的演变,传播动态和临床特征.
为了比较CRF07_BC_N (07BC_N) 和CRF07_BC_O (07BC_O) 血统的特征.
评估CRF07_BC中传染性耐药性 (TDR) 突变的发生率.

主要方法:

在2017年至2023年期间对上海新诊断的HIV-1患者进行监测.
通过下一代测序 (NGS) 获得了2508个pol序列和130个接近全长的CRF07_BC基因组.
分析了病毒载量,CD4+ T细胞数量,传播途径和宿主内部单核酸变体 (iSNV) 的多样性.

主要成果:

与07BC_O相比,07BC_N系在上海的流行率更高.
患有07BC_N的个体基线病毒载量较低,CD4+ T细胞数量较高.
07BC_N主要在与男性发生性关系的男性中传播,并取代了07BC_O; 07BC_O在南部省份的注射吸毒者和异性恋者中更为普遍.
在大多数基因中,07BC_O的iSNV数量明显高于07BC_N.
在CRF07_BC中TDR突变的总流行率为5. 7%.

结论:

在中国,CRF07_BC_N正在迅速扩张,特别是在中国东部的MSM中,并取代了CRF07_BC_O.
不同的临床和进化特征区分07BC_N和07BC_O,影响传播动态.
这些发现为中国的针对性公共卫生干预和HIV-1管理策略提供了关键的见解.

关键词:

时间表:艾滋病毒-1 基因组在宿主内部分子流行病学传输方式

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