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相关概念视频

Molecular Shape and Polarity03:37

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Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
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Chromatographic techniques are classified in three ways: the classification is based on the physical state of the stationary and mobile phases, how the mobile phase and the stationary phase contact each other, or through the chemical or physical processes that isolate the components of the sample. Typically, the mobile phase is either a liquid or gas, while the stationary phase is either a solid or a liquid layer applied to a solid surface.
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Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...
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通过圆转转 SLIM 离子流动性实现多个类固醇子类的分析

Cole L Frank1, Breland M Jones1, Emmaleigh Efird1

  • 1Clemson University, Department of Chemistry, Clemson, South Carolina 29634, United States.

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PubMed
概括
此摘要是机器生成的。

一个新的无损离子操纵结构 (SLIM) 系统通过改善低质量传输来增强类固醇分析. 这种进步为各种应用提供了精确的类固醇异构分离.

关键词:
离子运动质谱学类固醇无损离子操纵结构 (SLIM)

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科学领域:

  • 分析化学
  • 生物化学
  • 测谱学

背景情况:

  • 离子移动性质谱 (IM-MS) 对于类固醇分析至关重要,可提供复杂混合物的速度和分离.
  • 高分辨率离子移动 (HRIM) 技术在类固醇学中越来越多地使用,但对低分子量化合物仍然存在挑战.
  • 无损离子操纵结构 (SLIM) 是一种新兴的HRIM技术,具有对类固醇分析的潜力.

研究的目的:

  • 评估一种新的,针对低质量的SLIM系统,用于分析各种类固醇子类.
  • 评估系统在分离具有挑战性的类固醇异构体中的性能.
  • 将新SLIM平台的效率与传统设计进行比较.

主要方法:

  • 使用一个低质量定制的SLIM平台,
  • 确定碰撞截面 (CCS) 值,并将其与漂流管测量进行比较.
  • 对具有微小CCS差异的异构体进行分离性能评估.
  • 使用气和气,用圆转SLIM与90°转SLIM进行了定量比较.

主要成果:

  • 经过线性回归校正的SLIM CCS值与漂流管数据有很好的一致性,突出了对特定类别的校正因子的需求.
  • 该系统实现了 ΔCCS < 1% 的异构体的良好分辨率.
  • 与传统系统和气相比,使用气缓冲气显著改善了信号.

结论:

  • 低质量定制的SLIM系统对快速和有针对性的类固醇分析具有显著的前景.
  • 优化的SLIM平台增强了低分子量类固醇的分析,包括类固醇素,胆汁酸和激素.
  • 这项技术在生物医学,临床,食品,环境和反兴奋剂领域具有广泛的应用.