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Updated: Sep 9, 2025

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
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在创伤性视神经病变后与CNTF输送方向导向轴突再生相结合的定向多孔微管

Xiaobin Ren1, Qinying Huang1, Zhenyuan Xie2

  • 1State Key Laboratory of Eye Health, School of Ophthalmology & Optometry, Eye Hospital, Wenzhou Medical University, 270 Xueyuan Xi Road, Wenzhou, 325027, China.

Biomaterials
|September 1, 2025
PubMed
概括

这项研究引入了使用纳米纤维和纳米颗粒的双重药物输送系统,以促进神经再生和视神经受伤后的细胞存活. 这种创新方法在老鼠模型中成功增强了轴突再生并减少了细胞死亡.

关键词:
轴突再生神经干细胞衍生外体视神经压碎模型导向的多孔微管创伤性视神经病变

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Neurogenesis and Regeneration of Nervous Tissue01:15

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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