心血管,和新陈代谢健康:预防心力衰竭的可行愿景
John W Ostrominski1, Alice Y Y Cheng2, Adam J Nelson3
1Cardiovascular Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Lancet (London, England)
|September 1, 2025
概括
由于住院病例的增加, 预防心力衰竭至关重要. 专注于心血管,和新陈代谢健康提供了预防策略的新框架.
科学领域:
- 心脏病学
- 肝脏病学
- 代谢医学
背景情况:
- 心脏衰竭是全球可预防住院的首要原因.
- 在历史上只被视为心脏问题, 心脏衰竭现在被理解为复杂的多系统起源.
- 心血管,和新陈代谢疾病往往会导致心力衰竭.
研究的目的:
- 突出心血管,和代谢 (CKM) 疾病在心力衰竭的发病过程中的相互联系.
- 通过整合CKM健康来提出预防心力衰竭的可行的框架.
- 强调解决导致CKM疾病的病理生理和社会结构因素的重要性.
主要方法:
- 对心力衰竭风险因素的流行病学研究的审查.
- 对影响CKM健康的药物治疗的临床试验数据的分析.
- 综合证据将CKM疾病与心力衰竭的发病和进展联系起来.
主要成果:
- 流行病学数据证实心脏衰竭中经常出现心血管,脏和代谢功能障碍.
- 新兴的药物疗法在同时改善CKM健康方面表现出有效性.
- 流行病学和治疗证据的趋同表明有共同的疾病机制.
结论:
- 预防心力衰竭需要更广泛的视角,包括心血管,和新陈代谢健康.
- 对于预防心力衰竭而言,CKM疾病及其前例是关键的,往往被忽视的目标.
- 综合性CKM健康方法为心力衰竭预防的各个利益相关者提供了实用框架.
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