Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

15.8K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.8K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

2.9K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.9K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

3.1K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.1K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

516
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
516
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

2.6K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.6K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

14.1K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Nuclease-functionalized poly(styrene-b-isobutylene-b-styrene) surface with anti-infection and tissue integration bifunctions.

ACS applied materials & interfaces·2014
Same author

Validation of reference genes for RT-qPCR analysis of CYP4T expression in crucian carp.

Genetics and molecular biology·2014
Same author

Deguelin, a selective silencer of the NPM1 mutant, potentiates apoptosis and induces differentiation in AML cells carrying the NPM1 mutation.

Annals of hematology·2014
Same author

Design of a 6-DOF upper limb rehabilitation exoskeleton with parallel actuated joints.

Bio-medical materials and engineering·2014
Same author

SIFT algorithm-based 3D pose estimation of femur.

Bio-medical materials and engineering·2014
Same author

Estrogen receptors' neuroprotective effect against glutamate-induced neurotoxicity.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2014

相关实验视频

Updated: Sep 9, 2025

Author Spotlight: An Effective Traditional Chinese Medicinal Treatment for Chronic Obstructive Pulmonary Disease with Abdominal Distension
05:19

Author Spotlight: An Effective Traditional Chinese Medicinal Treatment for Chronic Obstructive Pulmonary Disease with Abdominal Distension

Published on: September 1, 2023

1.6K

南华汉族群中AGER基因变异与慢性阻塞性肺病易感性的关联

Tian Xie1, Wei Xiao2, Jie Zhao2

  • 1Department of Pulmonary and Critical Care Medicine, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, Hainan, China.

Annals of medicine
|September 1, 2025
PubMed
概括
此摘要是机器生成的。

AGER基因的遗传变异可能会防止慢性阻塞性肺病 (COPD). 在南方汉族人群研究中,特定的AGER基因变异与降低的COPD风险有关.

关键词:
时间表慢性阻塞性肺部疾病病例和对照研究遗传变体易受影响

更多相关视频

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

10.1K
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.1K

相关实验视频

Last Updated: Sep 9, 2025

Author Spotlight: An Effective Traditional Chinese Medicinal Treatment for Chronic Obstructive Pulmonary Disease with Abdominal Distension
05:19

Author Spotlight: An Effective Traditional Chinese Medicinal Treatment for Chronic Obstructive Pulmonary Disease with Abdominal Distension

Published on: September 1, 2023

1.6K
A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

10.1K
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.1K

科学领域:

  • 遗传学
  • 肺病学
  • 分子生物学

背景情况:

  • 慢性阻塞性肺病 (COPD) 是老年人死亡和残疾的主要原因.
  • AGER基因与呼吸系统疾病的发展有关,但其在COPD易感性方面的具体作用尚未完全理解.
  • 研究AGER的遗传变异对于了解COPD的发病过程至关重要.

研究的目的:

  • 检查AGER基因的遗传变异与发展COPD的风险之间的联系.
  • 确定与南方汉族人群中COPD易感性相关的特定AGER单核酸多态 (SNP).

主要方法:

  • 使用病例对照研究设计,将270名COPD患者与271名健康对照患者进行比较.
  • 使用MassARRAY iPLEX平台进行了AGER SNP的基因型鉴定.
  • 进行了物流回归和多因素缩小 (MDR) 分析以评估关联和相互作用,并对多重测试进行了FDR校正. 使用eQTL分析来探索监管效应.

主要成果:

  • 两种AGERSNP,rs3134941 (G基因组) 和rs3131300 (G基因组),与COPD风险的显著降低有关 (p < 0. 001).
  • 在MDR分析中,rs3131300被确定为COPD风险的最佳预测因子.
  • eQTL分析表明这些SNP会影响相关人体组织中的AGER mRNA表达.

结论:

  • AGER基因中的基因变异可能会对COPD产生保护作用.
  • 这些发现有助于了解COPD的遗传基础,并突出潜在的治疗目标.