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Updated: May 8, 2026

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在早期大脑发育期间,弱化TrkB信号对中部前额叶皮质的影响:使用母体分离模型进行比较研究

Ken-Ichi Ohta1, Hidetoshi Ujihara2, Haruki Kumei1

  • 1Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Behavioural brain research
|September 1, 2025
PubMed
概括

早期的生活压力会破坏脑源性神经营养因子 (BDNF) 信号传递,影响抑制性神经元和工作记忆. 然而,这种干扰本身并不能导致老鼠的持续社会缺陷.

关键词:
大脑衍生神经营养因子 (BDNF)母亲分离 (MS)中部前额皮层 (mPFC)帕瓦尔胺 (PV)社会行为素受体激酶B (TrkB) 的使用

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Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...