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通过诱导长期的神经保护,缓解手术前的神经认知障碍

Binhua Zou¹, Tingting Chen², Jianzhong Fan¹

¹Department of Rehabilitation Medicine, Nanfang Hospital, Southern Medical University, PR China.

Brain research bulletin

|September 1, 2025

概括

在老老鼠中,术前间歇性甲基突破刺激 (iTBS) 改善了麻醉后的恢复,并减少了认知能力的下降. 这种神经调节策略缓解了手术后的神经炎症和神经细胞亡.

科学领域:

神经科学
神经调节
老年学

背景情况:

在外科手术后的老年患者中,神经认知障碍 (PND) 显著影响.
间歇性达突发刺激 (iTBS) 是一种非侵入性神经调节技术,已被证明具有认知效益.
之前没有研究iTBS在预防PND方面的有效性.

研究的目的:

调查手术前iTBS在接受麻醉和手术的老老鼠中减轻PND的潜力.
评估iTBS对认知功能,神经炎症和神经元亡的影响.

主要方法:

在异氨酸麻醉和探索性腹腔切除之前,老鼠每天接受iTBS或假刺激.
使用莫里斯水迷宫 (MWM) 评估认知功能.
在手术后量化了海马微质两极化,促炎细胞因子和神经元亡.

主要成果:

在MWM患者中,iTBS治疗加速了麻醉恢复,并减少了术后认知缺陷.
在海马体中,iTBS的使用导致M1极化微质的减少和TNF-α水平的降低.
在 iTBS 组中观察到海马神经亡的显著减少.

结论:

术前的iTBS在老年人中显示出预防PND的治疗潜力.
通过减少M1类型的促炎因素和增强神经元弹性,iTBS可以发挥其保护作用.
这些发现表明iTBS是缓解麻醉和手术引起的认知障碍的有希望的策略.

关键词:

麻醉剂国际贸易银行神经炎症在外科手术期间的神经认知障碍通过的磁性刺激

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