荷尔蒙避孕药的使用和类型:不同的皮质醇模式和皮质醇与情绪的关系
Ally H Villeneuve1, Ayeila Z B Daneshmend1, Dana A Jarkas1
1Department of Neuroscience, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada; University of Ottawa Institute of Mental Health Research, 1145 Carling Avenue, Ottawa, Ontario K1Z 7K4, Canada.
与自然周期相比,荷尔蒙避孕药的使用没有改变压力或情绪. 然而,HC类型很重要,仅使用孕激素的患者报告的精神健康诊断和皮质醇水平低于联合口服避孕药的患者.
科学领域:
- 神经内分泌学
- 心理神经内分泌学
- 生殖健康
背景情况:
- 全球有数百万人使用荷尔蒙避孕药.
- HCs对情绪和神经内分泌功能的影响尚不清楚.
- 了解这些影响对于生殖健康和心理健康至关重要.
研究的目的:
- 研究HC使用对压力,情绪,生活质量和皮质醇模式的影响.
- 为了比较使用组合口服避孕药 (COCs) 和仅使用孕激素的HCs的患者.
- 探索皮质醇和心情之间的关系.
主要方法:
- 年轻的女大学生 (N=191岁) 填写了在线情绪/压力调查问卷.
- 采集了白天皮质醇样本.
- 用一个独立的复制样本 (N=411,年龄为19岁) 来验证结果.
主要成果:
- 在HC使用者和自然循环使用者之间没有观察到压力,情绪或白天皮质醇模式的显著差异.
- 皮质醇和情绪结果之间的明显相关性表明HC使用者有调节障碍.
- 结合口服避孕药 (COC) 使用者报告生活质量高于自然循环使用者.
- 与单纯孕激素使用者相比,单纯孕激素使用者更有可能报告精神健康诊断,并且血皮质醇水平较低.
结论:
- 与自然循环相比,HC使用并不普遍影响压力,情绪或皮质醇模式.
- 使用的HC类型显著影响生活质量,心理健康诊断和皮质醇水平.
- 这些发现突显了荷尔蒙避孕,神经内分泌功能和心理健康之间的复杂相互作用,强调了HC类型的重要性.
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