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锡图因调节心力衰竭中的巨分化:代谢重编程,表观遗传调节和免疫细胞相互作用

Ruifang Lin¹, Yun Zhu², Yongjun Liu²

¹School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China; Hunan Key Laboratory of Colleges and Universities of Intelligent TCM Diagnosis and Preventive Treatment of Chronic Diseases, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China.

Pharmacological research

|September 1, 2025

概括

锡图因调节巨细胞两极分化,这是心力衰竭 (HF) 的关键因素. 用天然化合物准这种Sirtuin-巨轴可能提供新的HF疗法.

科学领域:

心血管科学
免疫学
分子生物学

背景情况:

心力衰竭 (HF) 具有显著的发病率和死亡率,需要新的治疗方法.
人们越来越认识到巨分化在HF发育和进展中的作用.
NAD+依赖的Sirtuin脱乙酶家族通过代谢和表观遗传途径影响了巨细胞的两极分化.

研究的目的:

系统地审查Sirtuins (SIRT1-SIRT7) 在HF中调节巨分极的分子机制.
总结针对HF的Sirtuin-巨分极轴的植物药物的治疗潜力.
为开发以Sirtuin为媒介的巨分化为基础的HF疗法提供框架.

主要方法:

专注于巨分化中的Sirtuin功能的文献综述.
分析分子机制,包括代谢重编程和表观遗传调节.
自然化合物的概述及其对HF中的Sirtuin-巨轴的影响.

主要成果:

通过整合代谢转移 (葡萄糖,脂质,谷氨酸代谢) 和表观遗传变化 (DNA甲基化,基因组修饰,ncRNAs) 来调节巨分极.
植物药物如白醇,素和柏柏林在向Sirtuin巨细胞通路方面表现有前途.
这些天然化合物会影响巨细胞的两极分化,可能会影响HF的进展.

结论:

通过Sirtuin调节巨分极是HF的一个关键机制.
用植物药物准Sirtuin-巨轴为预防和治疗HF提供了一个有前途的策略.
这篇评论为开发基于天然产品的新型心力衰竭疗法提供了洞察力.

关键词:

表观遗传调节心脏衰竭免疫细胞的相互作用巨细胞的两极分化代谢重编程其他:

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