在多轴拉伸和压缩条件下研究骨肌肉结构机制的双相微结构模型
Benjamin B Wheatley1, Minhaj U Bhuiyan2, Sabrina S Lorza1
1Department of Mechanical Engineering, Bucknell University, USA.
Acta biomaterialia
|September 1, 2025
概括
这项研究开发了一种新的骨肌肉计算模型, 结合流体动力学, 来预测微观结构数据的被动材料特性. 这种模型有助于我们更好地了解肌肉机制,
科学领域:
- 生物力学
- 计算生物学
- 材料科学
背景情况:
- 被动骨肌肉特性对于力传递至关重要,但从微观结构数据预测它们仍然具有挑战性.
- 肌肉微观结构的变化可能会对组织功能产生负面影响,强调需要更好的预测模型.
研究的目的:
- 在多轴负荷下开发一个被动骨肌肉实验数据集.
- 创建和验证骨肌肉的双相微观结构计算模型.
- 确定影响肌肉机械行为的关键微观结构参数.
主要方法:
- 进行平面双轴和半封闭压缩实验,并测量肌肉压力.
- 开发了一个有限元素模型使用GIBBON工具箱与Voronoi类似的结构.
- 在肌肉纤维和细胞外基质中采用多域双相,异构,超粘弹性构成模型.
主要成果:
- 该模型与实验数据进行校准和验证,平均平方误差低 (0.5%21%).
- 参数研究表明肌肉纤维和细胞外矩阵的拉伸特性显著影响拉伸应力行为.
- 通过性被确定为压力-拉伸行为的一个关键因素,而ECM体积分数和纤维散装模量影响了这两者.
结论:
- 开发的双相微观结构模型准确地预测了被动骨肌肉的特性.
- 肌肉细胞,细胞外基质和液体之间的相互作用对肌肉的机械行为有很大影响.
- 这种模型可以增强肌肉组织的计算模拟,帮助研究液体流动和预防肌肉损伤.
相关概念视频
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Deformation occurs in axial and transverse directions when an axial load is applied to a slender bar. This deformation impacts the cubic element within the bar, transforming it into either a rectangular parallelepiped or a rhombus, contingent on its orientation. This transformation process induces shearing strain. Axial loading elicits both shearing and normal strains. Applying an axial load instigates equal normal and shearing stresses on elements oriented at a 45° angle to the load axis.
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01:08Bending of Members Made of Several Materials
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Hooke's Law determines stress in each material, stating that stress is proportional to strain but varies due to each...
Hooke's Law determines stress in each material, stating that stress is proportional to strain but varies due to each...
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