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Updated: Sep 9, 2025

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通过抑制单碳代谢来抑制NRF2

Julius Chembo1, Brittany M Bowman1, Kyle Lapak1

  • 1Department of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, MO, 63110.

The Journal of biological chemistry
|September 1, 2025
PubMed
概括

像WCDD115这样的甲胺衍生物通过向二叶酸还原酶 (DHFR) 有效抑制核因子红色素2相关因子2 (NRF2). 这为抗击NRF2驱动的癌症提供了新的策略.

关键词:
美国KEAP1 的使用情况其他类型一个碳代谢蛋白质组学甲胺

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