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Updated: Sep 9, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors

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糖酸脱酶与蛋白激酶TAK1相互作用并抑制,以减轻败血症冲击

Penghui Hu1, Zemin Ji2, Hui Xiong3

  • 1Department of Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin Institute of Immunology, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.

The Journal of biological chemistry
|September 1, 2025
PubMed
概括

糖酸脱酶 (PHGDH) 在败血症中降低调节,使炎症恶化. 在巨细胞中恢复PHGDH水平可以减少与败血症相关的炎症和器官损伤,从而提供新的治疗潜力.

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