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Updated: Sep 9, 2025

Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy
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UBE2C通过通过APC/CCDH1介导的WDR76降解稳定胰腺瘤发生

Linchen Wang1, Xiaoyu Chen2, Ruirui Qu1

  • 1Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Zhejiang Provincial Key Laboratory of Pancreatic Disease, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China; Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, Hangzhou, China.

Cancer letters
|September 1, 2025
PubMed
概括

通过破坏WDR76的稳定性,UBE2C促进胰腺癌,导致KRAS积累和MAPK通路激活. 针对UBE2C-WDR76轴为KRAS驱动的胰腺管腺癌提供了潜在的治疗方法.

关键词:
CDH1 其他美国国家安全局胰腺瘤发生一个UBE2CWDR76的时间

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