通过调节FoxO1的表达来缓解骨关节炎的进展,DAIDZIN抑制了内分泌网膜压力
Kaiye Chen1,2,3, Yangcan Jin1,2,3, Hao Chen1,2,3
1Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Phytotherapy research : PTR
|September 1, 2025
概括
一种大豆异黄素 - - 大津,对骨关节炎 (OA) 有治疗潜力. 它通过调节FoxO1信号来降低内质网压力,细胞亡和细胞外基质降解.
科学领域:
- 生物医学
- 药理学
- 骨关节炎研究
背景情况:
- 骨关节炎 (OA) 的发病包括内质网膜应激 (ERS) 和软骨细胞亡.
- 大 (DDZ) 是一种来自大豆的异黄,具有已知的抗氧化和抗动脉样性质.
- 研究DDZ在关节炎的治疗潜力是有必要的.
研究的目的:
- 评估大津 (DDZ) 对骨关节炎 (OA) 的治疗作用.
- 阐明戴津在瘤中作用的基本机制.
- 在体内 (小鼠DMM模型) 和体内 (TBHP诱导的状细胞) OA 模型中评估DDZ.
主要方法:
- 建立了一种小鼠中介半月不稳定 (DMM) 模型和一个TBHP诱导的体外OA状细胞模型.
- 利用网络药理识别可能与OA相关的Daidzin目标.
- 进行组织学 (HE,SO),成像学 (X射线,CT) 和分子分析以评估ERS,亡,ECM降解和FoxO1信号.
主要成果:
- 在OA模型中,戴津治疗上调了Forkhead Box O1 (FoxO1) 水平.
- 戴津显著抑制了内等质网压力 (ERS) 和冠状细胞亡.
- 在冠状细胞中减弱细胞外基质 (ECM) 降解.
结论:
- 在体内和体外的OA模型中,Daidzin表现出显著的治疗效果.
- 这种机制涉及FoxO1的上调,ESR的抑制,以及减少状细胞的亡和ECM降解.
- 戴津是一种有前途的治疗关节炎的候选药物.
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