感染性内心炎手术后存活的患者的长期死亡率与背景人群:全国性研究
Sikander Tajik Nielsen1, Jeppe K Petersen2, Katra Hadji-Turdeghal2
1Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark sikander.tajik.nielsen.02@regionh.dk.
Open heart
|September 1, 2025
概括
在感染性内心炎 (IE) 门手术中幸存的患者的长期死亡率和发病率高于一般人群. 这项研究强调即使在成功的手术后,风险也会持续增加,强调需要持续监测.
科学领域:
- 心脏病学
- 传染性疾病
- 手术的结果
背景情况:
- 感染性内心炎 (IE) 手术可以改善存活率,但存在重大风险.
- 与一般人群相比,对IE患者进行门外科手术后的长期结果尚不清楚.
- 这项研究调查了门手术后IE患者的长期死亡率和发病率.
研究的目的:
- 为了比较IE门手术幸存的患者的长期死亡率与匹配的背景人群.
- 评估IE患者的长期发病率,包括入院率.
- 提供IE对健康的持续影响及其手术管理的见解.
主要方法:
- 利用丹麦的注册表识别了1050名第一次IE的门手术后存活90天的患者 (2010-2023年).
- 根据年龄,性别和并发症对每个患者进行1:3的对照.
- 使用卡普兰-梅尔和考克斯模型评估5年和10年的全因死亡率;分析了第一年住院情况.
主要成果:
- 与对照组相比,IE患者 (n=1050) 的5年死亡率 (20. 1% 与 12. 9%) 和10年死亡率 (38. 5% 与 27. 9%) 显著更高.
- 在IE患者中,调整后的5年和10年死亡率仍然较高 (HR分别为1. 49和1. 38).
- 在手术后的第一年内,IE患者的住院时间更频繁和更长 (36. 8% vs 17. 5%).
结论:
- 与对照组相比,因IE而接受门手术的患者的原始死亡率较高.
- 即使对混因素进行调整,IE患者的5年和10年死亡率仍然较高.
- 这些发现强调了感染性内心炎及其手术治疗的长期不良健康后果.
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