固体恶性瘤患者的间歇性肺病流行病学和病因学:系统文献综述
Egbert F Smit1, Simon M Collin2, Manoj Prahladan2
1Department of Pulmonary Diseases, Leiden University Medical Center, Leiden, The Netherlands.
Future oncology (London, England)
|September 1, 2025
概括
癌症患者的间歇性肺病 (ILD) 可能是由于治疗或其他原因引起的. 及时治疗非药物诱导的ILD对于更好的癌症和ILD结果至关重要.
科学领域:
- 癌症学
- 肺病学
- 系统文献审查
背景情况:
- 间歇性肺病 (ILD) 是癌症患者已知的并发症.
- 在这一群体中,ILD可以是药物诱导的 (DI ILD),也可以是非药物相关的原因,如感染或其他疾病.
- 了解DI ILD和非DI ILD的流行病学和管理对于患者的护理至关重要.
研究的目的:
- 对癌症患者非DIILD的流行病学和病因学进行系统的文献审查.
- 研究固体癌症患者的DI ILD的治疗方法和结果.
- 在癌症治疗的背景下综合目前的ILD证据.
主要方法:
- 搜索主要数据库到2023年8月对ILD和固体癌症的研究.
- 手动搜索相关的会议记录 (2021-2023) 和文献.
- 包括报告ILD流行病学,临床管理和生存结果的研究,双独立审查员查.
主要成果:
- 包括55篇来自4,519个选记录的全文文章;37篇为提取数据的优先级.
- 这些研究主要是日本的回顾性队列研究,通常涉及用免疫检查点抑制剂治疗的肺癌患者.
- 对于非DI ILD存在有限的数据,通常与辐射或手术有关,而大多数研究集中在DI ILD的结果上.
结论:
- 缺乏关于非DIILD的证据凸显了迅速干预的需要.
- 在排除其他原因之后,有效的治疗ILD对于预防癌症和ILD的进展至关重要.
- 需要进一步的研究来阐明非DIILD在癌症患者.
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