在与心血管疾病风险因素相关的老年人中,CD4+ T 细胞及其子集上的免疫生物标志物CD57的表达占主导地位
Kanda Sornkayasit1, Chanvit Leelayuwat2, Amonrat Jumnainsong2
1Center of Excellence in Precision Medicine, Srinagarind Hospital, Khon Kaen University, Khon Kaen, Thailand.
Journal of leukocyte biology
|September 1, 2025
概括
老年人显示CD57+ T细胞增加,与心血管疾病风险因素和较高的炎症性细胞因子产生有关. 这表明年龄和心血管风险会影响免疫功能.
科学领域:
- 免疫学
- 老年学
- 心血管疾病研究
背景情况:
- CD57是已知的免疫性生物标志物,随着年龄的增长而增加表达.
- 与年龄相关的免疫系统变化会影响患心血管疾病 (CVD) 等慢性疾病的易感性.
研究的目的:
- 研究 CD4+ T 细胞表型和细胞因子 (IFN-γ,IL-17) 与衰老和心血管疾病风险因素的关系.
- 在老年人中确定CD57表达,T细胞子集和心血管疾病风险因素之间的关联.
主要方法:
- 用多色流细胞测量分析年轻 (≤35岁) 和老年 (≥60岁) 个体的全血样本.
- 分析的重点是CD4+ T细胞表型,包括CD57和CD28的表达,以及细胞内细胞因子的产生 (IFN-γ,IL-17).
主要成果:
- 与年轻人相比,老年人的CD4+CD57+和CD4+CD28- T细胞百分比显著高.
- CD57表达与CD4+CD28- T细胞具有正相关性. 患有心血管疾病风险因素的老年人 (失脂症,高血压,糖尿病) 显示CD4+CD57+,CD4+CD28-和CD4+CD28-CD57+T细胞水平升高.
- 与CD4+CD57- T细胞相比,在CD4+CD57+T细胞中观察到IFN-γ和IL-17的中位数较高. 具有心血管疾病风险因素的老年参与者具有显著更多的IFN-γ产生CD4+CD57+T细胞.
结论:
- 在CD4+T细胞及其子集上显著的CD57表达是老年人的特征.
- 随着年龄的增加和心血管疾病的危险因素与免疫功能的改变有关,IFN-γ和IL-17产生CD4+CD57+T细胞的增加证明了这一点,这可能导致慢性低度炎症.
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