通过单反应对多个thioether桥接的区域选择性合成
Nan Zhang1, Meiqi Wu1, Lijing Feng1
1College of Chemistry and Materials Science, Key Laboratory of Analytical Science and Technology of Hebei Province, and MOE Key Laboratory of Medicinal Chemistry and Molecular Diagnostics, Hebei University, Baoding 071002, Hebei, China.
The Journal of organic chemistry
|September 1, 2025
概括
通过SeODR策略,可以有效合成多种双环和糖. 这种单一的方法容纳了各种交叉链接剂,通过糖化产生复杂的循环.
科学领域:
- 有机化学
- 合成
- 糖化学
背景情况:
- 由于其增强的稳定性和功效,双循环 (BPs) 在药物发现中至关重要.
- 现有的BP合成方法通常涉及多个步骤和有限的结构多样性.
- 这种SeODR策略为改和循环化提供了一个有前途的方法.
研究的目的:
- 适应并应用SeODR策略用于合成多种双循环 (BPs).
- 开发基于单糖的新型交叉链接剂,用于制造双循环糖联体 (BGPs).
- 合成复杂的三环糖结合物 (TGP),证明了组合策略的多功能性.
主要方法:
- 在BP合成中使用SeODR (驱动的氧化去除和重新排列) 策略.
- 通过m-xylyl与葡萄糖,曼诺斯和银糖的点击化学结合制备的基于单糖的新型交叉链接剂.
- 采用单反应方法合成BP,BGP和TGP.
主要成果:
- 成功合成了15个双环 (BPs),具有不同结的良好产量.
- 证明了多个交叉链接剂 (xylyl,BBP,BBMP,DCA,DCTZ) 与SeODR方法的兼容性.
- 通过使用SeODR策略和新型交叉链接剂,首次合成了7种双循环糖联体 (BGPs) 和1种三循环糖联体 (TGP).
结论:
- 对于结构多样化的双循环的单合成,SeODR策略非常有效.
- 开发的单糖基交联剂与SeODR方法兼容,使BGP合成成为可能.
- 组合策略为构建复杂的,糖化循环提供了方便和多功能平台.
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