脊柱和骨盆关联通道将从小鼠结肠传递到不同的脑干电路
QingQing Wang1,2, Alice E McGovern3, Melinda Kyloh4
1Visceral Pain Research Group, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Journal of neurochemistry
|September 1, 2025
概括
通过大肠和骨盆神经传递感官信息, 整合到不同的脑干区域. 这项研究绘制出这些通道的地图, 揭示了肠-大脑沟通中的独特作用.
科学领域:
- 神经科学
- 胃肠病学
- 内脏疼痛研究
背景情况:
- 结直肠通过明显的脊柱和骨盆 afferent神经通道接收感官输入.
- 了解这些通路的中心整合对于破译结肠直肠感官运动功能和内脏疼痛机制至关重要.
研究的目的:
- 识别大脑干区域,其中来自大肠和骨盆 afferent神经的感觉信息汇聚.
- 阐明这些附带通路在向大脑传输结直肠感官信息中的特定作用.
主要方法:
- 使用跨神经病毒标记物 (简单疹病毒-1 H129-EGFP) 注入远端结肠以绘制上升的投影.
- 在体内使用有害结直肠扩张 (CRD),然后对化ERK (pERK) 进行免疫标记以识别激活的神经元.
- 研究了背部根结节 (DRG) 移除骨和骨盆 afferent神经元对CRD引起的神经元激活的影响.
主要成果:
- 病毒追踪器揭示了神经髓,突和中脑结构的上升输入, 参与感官中继,疼痛调节和自主控制.
- CRD激活了大脑干区域的神经元,这些神经元也获得了病毒标记,证实了大肠直肠信号的参与.
- 在尾部腹侧髓,正面腹中髓和侧侧脊核中,去除状DRG显著降低了CRD引起的激活.
- 移除盆腔DRG显著降低了前腹中枢髓,侧侧核,巴林顿核和周水管灰细胞中CRD引起的激活.
结论:
- 从大肠直肠到不同的脑干核.
- 这些发现为每条通道对肠-大脑轴的独特贡献提供了新的见解.
- 这项研究提高了我们对大肠直肠传感处理及其在肠-大脑沟通中的作用的理解.
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