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在转移性黑色素瘤中,成熟和迁移性树突细胞促进免疫透和对抗PD-1检查点阻塞的反应

Jiekun Yang1,2,3,4, Cassia Wang5, Doris Fu5

  • 1Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA. jackie.yang@rutgers.edu.

Nature communications
|September 1, 2025
PubMed
概括

一种新的成熟树突细胞亚型 (mregDC) 预测了黑色素瘤免疫治疗的成功. 高水平的mregDC,特别是特定的T细胞比率,改善了患者的结果,并指导了未来的癌症治疗.

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Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...