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Updated: Sep 9, 2025

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多发性骨髓瘤相关的长非编码RNA PLUM通过增强PRC2介导的UPR通路激活来赋予化学抵抗

Kamalakshi Deka1, Jean-Michel Carter1, Akash Bahai1

  • 1School of Biological Sciences (SBS), Nanyang Technological University (NTU), Singapore, Singapore.

Nature communications
|September 1, 2025
PubMed
概括

一种新的长非编码RNA,PLUM,通过稳定PRC2复合体来驱动多发性骨髓瘤 (MM) 的化学抵抗. 针对PLUM-EZH2相互作用使耐火性MM细胞重新敏感.

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