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在正常葡萄糖耐受性和2型糖尿病捐赠者的胰腺部分的空间转录学数据集

Nick Howell1, Zoe Weiss1, Lori L Bonnycastle1

  • 1Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

Scientific data
|September 1, 2025
PubMed
概括

空间转录学揭示了胰腺中的基因表达模式. 一种新的方法纠正了转录出血,改善了2型糖尿病 (T2D) 和正常葡萄糖耐受性 (NGT) 胰腺组织的分析.

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The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
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