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Updated: Sep 9, 2025

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
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Published on: December 22, 2020

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在瘤中,AEBP1驱动纤维细胞介导的T细胞功能障碍

Xiaoyu Wang1, Jie Li1,2, Daqiang Song1

  • 1Department of Breast and Thyroid Surgery, Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Nature communications
|September 1, 2025
PubMed
概括

脂肪细胞增强结合蛋白1 (AEBP1) 导致癌症T细胞功能障碍,阻碍免疫治疗. 在与癌症相关的纤维细胞中抑制AEBP1增强了抗瘤免疫力和患者的结果.

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