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在小鼠关节组织中识别感觉纤维类型

Jessie J Alfaro¹, Exing Wang²,

¹Integrated Biomedical Sciences (IBMS) Program, The School of Medicine, The University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, TX, 78229, USA.

Scientific reports

|September 1, 2025

概括

这项研究确定了小鼠关节 (TMJ) 组织中的神经类型,发现主要是体感觉纤维和缺乏非感觉神经,这对于理解TMJ疾病至关重要.

科学领域:

神经科学
人体解剖学
疼痛研究

背景情况:

关节 (TMJ) 疾病与关节组织的神经敏感性增加有关.
了解特定的神经群体对于调查关节疾病机制至关重要.

研究的目的:

识别和描述小鼠TMJ组织中存在的感觉和交感神经类型,包括后盘组织,前盘和关节囊.
建立未来研究TMJ疾病的神经生物学基础的基准.

主要方法:

使用免疫组织化学 (IHC) 检测特定的神经元标记物.
使用记者小鼠可视化和量化不同神经纤维群.
使用了全感官标记物pgp9. 5,以及性 (CGRP),非性 (NFH) 和其他感官 (Htr3a,Mrgpr,体质素,帕瓦胺) 和交感 (TH) 纤维的标记物.

主要成果:

关节盘缺少神经;其他肌组织包括70%的非髓和30%的髓纤维.
感觉纤维主要是CGRP+ 体 (在后盘中约80%,几乎全部在囊/ 前盘中).
没有非毒感性A-LTMRs (CGRP-/ NFH+). 有大量的Htr3a+纤维 (全部在囊/前盘中,60- 70%在后盘中). 复盘组织显示约20%的Mrgpr+纤维. 血管通过感觉和同情神经 (TH+) 进行神经化.

结论:

鼠标的肌关节组织主要由体感觉纤维化,其它非体感觉亚型的存在极小.
缺少A-LTMR表明,鉴定出的神经纤维在关节的感觉和病理方面具有特定的作用.
这些发现提供了关键的解剖数据,以了解关节内置,并制定针对关节疾病的治疗策略.

关键词:

前盘关节性圆盘血管血管联合囊类动物复盘组织感官神经元其他类型长关节 (TMJ) 的情况

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