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从殖民到感染:评估KPC,NDM,VRE和CRAB直肠殖民患者的BSI潜力

Marta Colaneri^1,2, Paola Giordani³, Simone Milanesi⁴

¹Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.

Infectious diseases and therapy

|September 1, 2025

概括

多种耐药生物 (MDRO) 如耐卡巴胺的肠杆菌 (KPC,NDM) 和耐卡巴胺的宝曼菌 (CRAB) 具有显著的血液感染 (BSI) 风险. 重症监护室 (ICU) 住院和特殊情况增加了殖民患者的BSI可能性.

科学领域:

传染性疾病
临床微生物学
医院流行病学

背景情况:

鼻腔感染通常是由多抗药生物体 (MDRO) 引起的.
关键的MDRO包括耐卡巴胺的肠杆菌 (KPC,NDM),耐卡巴胺的宝曼菌 (CRAB) 和耐胺的菌 (VRE).
患有MDRO的患者面临患有血液感染 (BSI) 的风险增加.

研究的目的:

研究与特定MDROs结合的患者患血流感染 (BSI) 相关的危险因素.
确定哪些MDRO和患者特征与增加的BSI风险相关.
为高风险患者群体制定有针对性的预防策略.

主要方法:

对KPC,NDM,VRE或CRAB的直肠殖民患者进行了回顾性研究.
在2019年1月至2024年10月期间从医疗,外科和ICU病房收集的数据.
使用后勤回归分析来确定负债表发展的独立风险因素.

主要成果:

在1960年特定的MDRO入院患者中,整体BSI率为9.4%.
CRAB (20.0%) 和KPC (12.6%) 的资产负债率最高.
在ICU住院增加了KPC,NDM和VRE的BSI风险. 血液恶性瘤/移植和固体器官移植是特定的MDROBSI的独立风险因素.

结论:

在不同的MDRO中,BSI风险差异很大,CRAB和KPC是最关键的.
在ICU和血液或固体器官移植的患者尤其容易受到伤害.
这些发现强调了针对重症患者和免疫受损患者的定制预防策略的必要性.

关键词:

血流感染后勤回归多药耐药生物结直肠殖民危险因素

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