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Updated: Sep 9, 2025

Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice
05:08

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Published on: October 3, 2019

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对慢性cAMP压力的高效心脏蛋白质适应失败与心脏加快衰老有关

Maria Grazia Perino1, Miguel Calvo-Rubio Barrera2, Daniel R Riordon3

  • 1Laboratory of Cardiovascular Science, Intramural Research Program, National Institute On Aging, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD, 21224, USA. mariagrazia.perino@nih.gov.

GeroScience
|September 1, 2025
PubMed
概括

衰老会影响心脏蛋白质稳定. 由于心脏循环腺单 (cAMP) 过度表达的年轻小鼠表现出增强的蛋白质质量控制,而老年小鼠由于过度表达的机制而发展出蛋白质毒性压力和心肌病.

关键词:
年龄增长不调节的蛋白质静止蛋白质质量控制

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