在无形性皮肤炎中定义"火焰":叙述性综述
Joseph F Merola1, Stephan Weidinger2, Sally Y Tan3
1Department of Dermatology and Department of Medicine, Division of Rheumatology, O'Donnell School of Public Health, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, USA. joseph.merola@UTSouthwestern.edu.
American journal of clinical dermatology
|September 1, 2025
概括
对于有效的治疗来说,定义阿托皮性皮肤炎 (AD) 发作至关重要. 目前的研究缺乏共识,大多数定义依赖于临床医生的报告而不是患者的经验.
科学领域:
- 皮肤病学
- 临床研究
- 患者报告的结果
背景情况:
- 无形性皮肤炎 (AD) 是一种慢性炎症性皮肤疾病,对生活质量有重大影响.
- 阿尔茨海默病的爆发需要进行治疗调整,但缺乏普遍接受的定义.
- 这阻碍了预防和管理爆发的研究.
研究的目的:
- 重新审视目前有关亚托皮性皮肤炎爆发的框架和定义.
- 分析指南,临床试验和观察性研究中使用的定义.
- 在阿尔茨海默病爆发研究中强调以患者为中心的定义的必要性.
主要方法:
- 系统文献评论的叙述性审查.
- 对美国和欧洲关于AD爆发定义的指导方针的审查.
- 随机对照试验和观察性研究中的爆发定义分析 (2014年1月至2024年9月).
主要成果:
- 目前在阿尔茨海默病研究中使用了各种各样的爆发定义.
- 大多数确定的定义优先考虑临床医生报告的结果.
- 很少有定义包含患者对疾病爆发的看法.
结论:
- 缺乏对AD爆发的明确可衡量定义的共识阻碍了研究.
- 现有的定义主要依赖于临床医生的评估.
- 纳入患者的观点对于制定临床相关和验证的AD爆发定义至关重要.
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