在COPD患者中,BRI与全因和心血管死亡率之间的关联
Riken Chen1, Yuli Cai1, Qinghua Chen1
1The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524003, China.
身体圆度指数 (BRI) 与慢性阻塞性肺病 (COPD) 患者的死亡率较高有关. 较高的BRI分数表明COPD所有原因和心血管死亡的风险增加.
科学领域:
- 肺部医学
- 心脏病学
- 生物统计学
背景情况:
- 腰围与慢性肺炎恶化有关.
- 在COPD患者中,身体圆度指数 (BRI) 的预后值尚不清楚.
研究的目的:
- 在COPD患者中研究BRI与全因和心血管死亡率之间的关联.
- 评估BRI对这一群体的死亡率的预测性能.
主要方法:
- 从NHANES (1999-2018) 中对3672名COPD参与者的分析.
- 使用多变量考克斯比例危险模型,卡普兰-梅尔分析和限制立方线分析.
- 通过ROC曲线评估BRI的预测准确性,并进行子组分析.
主要成果:
- BRI与所有原因和心血管死亡率的增加有显著关联.
- 较高的BRI四分位数与降低的生存率和增加的累积死亡率相关.
- 与其他模型相比,BRI对死亡率的预测性能更好.
结论:
- BRI是COPD患者死亡的一个重要预测因素.
- 升高的BRI与所有原因和心血管死亡的风险增加有关.
- BRI可以作为减少COPD死亡率的干预目标.
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