在急性ST段升高心肌梗塞患者中,甘油三指数的动态变化与预后之间的关联
Haiyan Jia1, Weifeng Zhang2, Shengqi Jia3
1Department of Cardiology, Affiliated Hospital of Hebei University, Baoding, 071000, Hebei, China.
Cardiovascular diabetology
|September 2, 2025
概括
在ST升高心肌梗塞 (STEMI) 后,显著的甘油三指数 (TyG) 轨迹预测了长期的心血管结果. 持续高的TyG指数表明风险增加,为二次预防策略提供信息.
科学领域:
- 心脏病学
- 代谢综合征
- 生物标志物
背景情况:
- 胰岛素耐药性的标志物 - - 三糖 (TyG) 指数与心血管事件有关.
- 以前的研究经常使用单个测量,缺少STEMI后的动态TyG指数变化.
研究的目的:
- 在ST升高心肌梗塞 (STEMI) 患者中研究不同甘油三指数 (TyG) 轨迹与长期结果之间的关联.
- 确定STEMI后 TyG指数变化的不同模式及其预后意义.
主要方法:
- 在接受PCI治疗的1092名STEMI患者中进行了回顾性队列研究.
- 在基线和出院后3,6,9,12个月测量TyG指数.
- 基于组的轨迹建模 (GBTM) 确定了TyG轨迹; 考克斯回归和卡普兰-梅尔分析评估了MACE关联.
主要成果:
- 确定了三种TyG指数轨迹:持续高 (n=92),中等 (n=196) 和快速下降 (n=804).
- 快速下降的组比持续高的组显著降低主要心血管不良事件 (MACE) 的发生率 (P< 0. 001).
- 独立预测患者结果的TyG指数轨迹.
结论:
- 在STEMI后,显著的TyG指数轨迹与长期预后有关.
- 持续高的TyG指数轨迹可以确定心血管风险较高的患者.
- 监测TyG指数的动态可能有助于STEMI幸存者的二次预防策略.
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