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Updated: Sep 9, 2025

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
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通过调节Tregs的PD-1驱动乳腺癌中的免疫抑制

Giovanna Talarico1,2, Mara Lecchi3, Anna Zanichelli1

  • 1Molecular Immunology Unit, Experimental Oncology Department, Fondazione IRCCS Istituto Nazionale Dei Tumori di Milano, Milan, Italy.

Journal of experimental & clinical cancer research : CR
|September 2, 2025
PubMed
概括

高度乳腺癌中的细胞外基质 (ECM) 影响T细胞. 在ECM3阳性瘤中,SPARC蛋白抑制T细胞活性,这表明除了PD-1/ PD- L1阻断之外还有新的治疗点.

关键词:
乳腺癌在 ECM3 签名细胞外基质一个IL-23免疫抑制美国在SPARC一个T细胞其他

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