评估各种婴儿配方补充剂的双生效:随机对照试验的系统审查和网络元分析
Fatemeh Mansouri1,2, Mahnaz Mardani3,4, Maryam Rezapour5
1School of Advanced Studies, University of Camerino, Camerino, Italy.
Journal of developmental origins of health and disease
|September 2, 2025
概括
用益生菌,协生菌或β-棕酸补充的婴儿配方可显著增加肠道中的有益的Bifidobacterium水平. 益生菌配方最接近母乳养婴儿的肠道细菌.
科学领域:
- 微生物组研究
- 婴儿营养
- 胃肠病学
背景情况:
- 婴儿的肠道微生物对健康和发育起着至关重要的作用.
- 哺乳促进了富含Bifidobacterium的肠道环境, 奶粉养的婴儿往往缺乏这种环境.
- 各种婴儿配方料旨在增强婴儿肠道微生物群的组成.
研究的目的:
- 对随机对照试验 (RCT) 进行系统审查和网络元分析 (NMA).
- 研究不同婴儿配方剂对婴儿肠道Bifidobacterium水平的影响.
- 将补充配方与标准配方和母乳养的双生效应进行比较.
主要方法:
- 在主要数据库 (PubMed,EMBASE,MEDLINE,Scopus,Web of Science,Cochrane CENTRAL) 中进行系统的文献搜索.
- 包括以益生菌,益生菌,共生菌,β-棕酸或组合补充剂评估的RCT.
- 用母乳养作为参考,对比Bifidobacterium的相对丰度 (RA).
主要成果:
- 与标准配方相比,补充益生菌,协生菌,β-棕酸或β-棕酸与益生菌显著增加了Bifidobacterium水平.
- 益生菌补充剂对Bifidobacterium水平没有显著影响.
- 补充了益生菌的配方表现出与母乳养婴儿观察到的效果最接近的双生菌效应.
结论:
- 用益生菌,协生菌和β-棕酸补充配方有效地增加了婴儿肠道中的Bifidobacterium丰富度.
- 富含益生菌的配方提供了一个有前途的方法来模仿母乳养婴儿的有益肠道微生物群.
- 由于观察到的群体变异性,可能需要进一步的研究来探索特定的益生菌和益生菌菌株的影响.
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