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Updated: Sep 9, 2025

Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells
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Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells

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导致ALS的C9orf72突变导致核素Nup107的错位化和聚合成压力颗粒

Saygın Bilican1,2, Yara Nabawi1,2, William Hongyu Zhang1,2

  • 1Institute for Integrated Stress Response Signaling, Faculty of Medicine, University Hospital Cologne, Germany.

FEBS letters
|September 2, 2025
PubMed
概括

研究人员发现,Nup107与受C9orf72基因突变影响的运动神经元中的压力颗粒相互作用,这是肌缩侧面硬化症 (ALS) 的关键因素. 减少Nup107在虫中改善了与ALS相关的症状.

关键词:
肌缩性侧面硬化类植物核氨酸蛋白质静止压力颗粒iPSC疾病的建模

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