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在固体瘤治疗中将L-氨酸聚合成纳米细胞的免疫代谢工程

Jia-Xin An¹, You-Teng Qin¹, Ying Tang¹

¹Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, 430072, P.R. China.

Angewandte Chemie (International ed. in English)

|September 2, 2025

概括

具有营养储存和免疫增强涂层的工程巨细胞增强了采用细胞疗法. 这种策略克服了营养缺乏的瘤环境,提高了抗瘤活性和对固体瘤的疗效.

科学领域:

免疫学
生物技术
癌症研究

背景情况:

采用细胞治疗的有效性取决于输入的细胞功能.
瘤微环境 (TME) 通常缺乏营养,阻碍抗瘤活性.
在TME内的免疫抑制限制了治疗潜力.

研究的目的:

增强营养缺乏TME的巨细胞功能,用于采用细胞治疗.
制定持续营养供应和转移细胞的免疫调节策略.
提高巨细胞对固体瘤的抗瘤功效.

主要方法:

整合采用转移的巨细胞与基于L-素的纳米细胞用于营养储存.
用细菌外膜囊泡涂层的纳米细胞具有免疫调节能力.
在体内评估了巨细胞活动,免疫反应和瘤生长抑制.

主要成果:

纳米细胞提供了持续的L-氨酸供应,优化了营养缺乏TME的巨细胞功能.
细菌外膜囊泡覆盖激活了巨细胞,使其具有抗瘤表型和免疫抵抗力.
改造的巨细胞显示出增强的瘤杀伤能力,并显著抑制了固体瘤的生长.

结论:

这种方法有效地调整了体内转移的细胞行为.
综合免疫代谢调节策略为增强采用细胞疗法提供了一个有前途的方法.
这项研究表明, 通过基于细胞的疗法治疗固体瘤可能会取得突破.

关键词:

免疫疗法氨酸巨细胞代谢过程纳米微粒

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