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Updated: Sep 9, 2025

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli
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在 ε-Poly-Lysine 生物合成,高产品菌株的选择和调控机制方面的进展

Jing-Yang Cai1, Cun-Jin Zhang1, Jia-Qi Wang1

  • 1Henan Provincial Key Laboratory of Grain Resources Conservation and Utilization, College of Biological Engineering, Henan University of Technology, Zhengzhou, China.

Biotechnology journal
|September 2, 2025
PubMed
概括

一种安全的抗微生物多,具有广泛的疗效. 本综述详细介绍了其生物合成,抗菌作用以及通过菌株改进和代谢工程增强e-PL生产的策略.

关键词:
生物合成生产情况监管机制聚氨酸

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相关概念视频

Stringent Response in E. coli01:23

Stringent Response in E. coli

Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...
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