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韩国冷米酒 (Makgeolli) 对小鼠洛佩拉胺引起的便秘的肠功能和肠活动的影响

Soyoung Jung¹, Yunjung Lee², Yoo Kyoung Park¹

¹Department of Medical Nutrition, AgeTech-Service Convergence Major, Kyung Hee University, Yongin 17104, Republic of Korea. ypark@khu.ac.kr.

Food & function

|September 2, 2025

概括

在大鼠便秘模型中改善了肠道功能并减少了DNA损伤. 这项研究表明Makgeolli可以缓解便秘的抗氧化和抗炎作用.

科学领域:

胃肠病学
药理学
营养科学

背景情况:

便秘是全球普遍存在的胃肠道疾病.
韩国传统的酒makgeolli含有有益于肠道健康的益生菌和酵母
关于Makgeolli对肠道功能的特定影响的经验研究有限.

研究的目的:

研究Makgeolli对肠道功能和肠道活动的影响.
在洛佩拉胺诱导的老鼠便秘模型中评估Makgeolli的疗效.
评估Makgeolli与便秘有关的潜在抗氧化和抗炎性质.

主要方法:

在Sprague-Dawley大鼠中建立了洛佩拉胺诱导的便秘模型.
鼠被分为四组:正常对照,洛佩拉胺诱导,洛佩拉胺 + 硫酸盐 (阳性对照) 和洛佩拉胺 + 麦格奥利.
治疗持续了两周,随后对便参数,胃肠道传输,DNA损伤,酶活性,氧化应激标志物和炎症细胞因子表达进行了分析.

主要成果:

与仅服用洛佩拉米德的组相比,Makgeolli治疗显著改善了便参数和胃肠道通道.
观察到结肠DNA损伤,有害肠道酶活性和氧化应激标志物的显著减少.
在Makgeolli治疗组中,结肠组织中的促炎性细胞因子mRNA表达 (COX- 2,INOS,TNF-α) 显著下降.

结论:

麦格罗利具有改善肠道功能和促进排便的功能性食物的潜力.
麦格罗利具有抗氧化和抗炎作用,可能有助于缓解便秘.
进一步的研究支持Makgeolli在控制便秘和促进胃肠道健康方面的作用.

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