出生体重,发生痴呆的风险和PET粉样蛋白负担:ARIC研究
Olivia M Emanuel1,2, Mark Lee3, Pamela L Lutsey4
1National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|September 2, 2025
概括
低出生体重并没有增加痴呆风险. 高出生体重与黑人成年人的痴呆症有关,而不是白人成年人. 出生体重没有影响粉样β水平.
科学领域:
- 神经学
- 流行病学
- 老年学
背景情况:
- 出生体重 (BW),痴呆风险和粉样β (Aβ) 病理之间的关系尚不清楚.
- 研究BW等早期因素可能有助于了解痴呆症的病因.
研究的目的:
- 检查出生体重 (BW) 与发生痴呆症之间的关系.
- 探索BW与粉样β (Aβ) 沉积之间的关系.
- 调查可能存在的BW痴呆症种族差异.
主要方法:
- 对10476名社区动脉样硬化风险 (ARIC) 研究参与者的分析,将BW分为低 (<5. 5磅),中等 (5. 5至9. 0磅) 或高 (> 9. 0磅).
- 通过2019年对事件痴呆症的跟进.
- 一个子组 (N=312) 接受了Aβ成像的florbetapir正电子发射断层扫描 (PET).
- 统计模型 (Cox比例危险,后勤回归) 调整为共变量,并根据种族对效应的修改进行探索.
主要成果:
- 低体重和早产都没有增加痴呆风险.
- 高血量与黑人参与者的痴呆风险增加有关 (aHR=1. 95,95% CI 1. 33-2. 86),但与白人参与者的血量不相关 (P- 相互作用=0. 001).
- 在PET成像中没有发现BW和Aβ沉积之间的显著关联.
结论:
- 低出生体重与痴呆或Aβ病理没有关联.
- 高出生体重与痴呆风险之间的关联取决于种族,主要观察到黑人成年人.
- 需要进一步研究以阐明出生体重在痴呆症复杂病因中的作用.
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