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Updated: Sep 9, 2025

In Utero Electroporation of Multiaddressable Genome-Integrating Color MAGIC Markers to Individualize Cortical Mouse Astrocytes
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在发育过程中产生明确的重组活动的星细胞选择性CRE驱动线

Yukina Izumi1, Tomoya Nakatani1, Harumi Takai1,2

  • 1Eisai Co. Ltd. Kobe Research Laboratories, Kobe, Japan.

Genesis (New York, N.Y. : 2000)
|September 2, 2025
PubMed
概括

研究人员开发了两种新的遗传工具Slc7a10-IRES-Cre和Aldh1l1-IRES-Cre,用于精确研究星球细胞. 这些CRE驱动线能够在星球细胞中进行选择性基因操纵,帮助大脑发育和功能研究.

关键词:
创建删除线星球细胞细胞系差异化

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Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
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