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癌细胞检测和精确向药物输送

Malabika Ghosh¹, Uddipan Dasgupta¹, Sourav Barman²

¹Amity Institute of Nanotechnology, Amity University Kolkata, Major Arterial Road, AA II, Newtown, Kolkata, West Bengal 700135, India.

ACS applied bio materials

|September 2, 2025

概括

叶酸脂质体 (FA脂质体) 显示出癌细胞检测和向药物输送的前景. 这种方法通过将抗癌药物Doxorubicin集中在癌细胞内,从而最大限度地减少对健康组织的伤害,从而提高治疗效果.

科学领域:

纳米医学
癌症诊断
药物输送系统

背景情况:

针对癌细胞进行检测和药物输送仍然是一个重大挑战.
叶酸是一种向性联体,与癌细胞过度表达的叶酸受体 (FR) 结合.
脂质体为药物封装和向输送提供了多功能平台.

研究的目的:

评估叶酸脂质体 (FA脂质体) 用于选择性癌细胞检测.
使用FA-脂质体 (FA-Lip-Dox) 评估多克索鲁比辛 (Dox) 的向输送.
研究FA-Lip-Dox在癌症治疗中的潜力,减少非目标效应.

主要方法:

用叶酸对脂质体进行共价结合,以提高向性.
在FA-脂质体内封装Doxorubicin以产生FA-Lip-Dox.
在癌症 (U87MG,KB) 和非癌症 (CHO) 细胞系中使用光成像和流细胞测量评估FA-Lip-Dox的向效率和药物递送.

主要成果:

在FR过度表达的癌细胞 (KB) 中,FA-Lip-Dox表现出选择性的向和积累.
在癌细胞中观察到显著的 doxorubicin 透,而在非向细胞中则可忽略不计的积累.
对正常细胞的细胞毒性较低,表明安全性较好.

结论:

FA-Lip-Dox有效地针对癌细胞进行检测和药物输送.
这种向的纳米载体系统最大限度地提高了治疗效果,同时降低了对健康细胞的毒性.
FA-Lip-Dox具有促进癌症治疗策略的巨大潜力.

关键词:

生物仿真策略生物传感器功能化的脂质体纳米载体有针对性的药物输送目标连接体

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