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  3. 两个中欧人口的身体功能与认知之间的性别差异
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  3. 两个中欧人口的身体功能与认知之间的性别差异

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两个中欧人口的身体功能与认知之间的性别差异

Tatyana Court1, Naděžda Čapková2, Andrzej Pająk3

  • 1RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic.

European journal of neurology
|September 2, 2025

在PubMed 上查看摘要

概括
此摘要是机器生成的。

综合体功能评分 (PFS) 预测认知能力下降,特别是在女性身上. 改善身体功能可能有助于保持认知健康,

关键词:
认知障碍身体功能得分预测模型性别差异年龄

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科学领域:

  • 老年学
  • 认知神经科学
  • 公共卫生

背景情况:

  • 身体和认知功能之间的联系是有争议的,对性别差异的研究有限.
  • 这项研究调查了PFS对认知功能的预测能力,考虑了东欧的性别特异性影响.

研究的目的:

  • 评估复合物理功能评分 (PFS) 对认知功能的预测值.
  • 评估东欧人口中PFS和认知状态之间的性别相关性.

主要方法:

  • 从捷克和波兰的HAPIEE研究中分析了7309名参与者 (平均年龄为59岁).
  • 从23项指标中得出的PFS包括日常生活活动,握力,功能限制和体力活动.
  • 通过标准化测试评估认知功能;用于分析关联的逻辑回归,调整为共变量. 模型性能使用AUC-ROC和交叉验证进行评估.

主要成果:

  • 在PFS和认知障碍之间观察到剂量依赖的关系 (中度的OR为1.15,低PFS为1.79).
  • PFS 显示出对认知功能的显著预测能力 (AUC = 0. 75).
  • 性别差异很明显:与PFS较高的女性相比,中度/低PFS的女性的认知障碍风险分别高出44%和100%. 在男性中,这种联系较弱.

结论:

  • 综合体功能评分 (PFS) 作为认知衰退的实际预测指标,在女性中尤为强烈.
  • 旨在增强身体功能的干预措施对保持认知健康至关重要,尤其是在老年女性中.
  • 建议进行进一步的纵向研究以验证这些发现并探索因果机制.